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HelpTest Code E1 Estrone, Serum
Additional Codes
Outreach (Atlas) Order Code
ESTRONE
Hospital (Cerner) Order Code
E1
Reporting Name
Estrone, SUseful For
As part of the diagnosis and workup of precocious and delayed puberty in females and, to a lesser degree, males
As part of the diagnosis and workup of suspected disorders of sex steroid metabolism (eg, aromatase deficiency and 17 alpha-hydroxylase deficiency)
As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
Monitoring low-dose female hormone replacement therapy in postmenopausal women
Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
Testing Algorithm
For information see Steroid Pathways.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.2 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: For more information see Steroid Pathways.
Specimen Minimum Volume
0.7 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Special Instructions
Reference Values
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-16 pg/mL |
|
Stage II |
11.5 years |
Undetectable-22 pg/mL |
|
Stage III |
13.6 years |
10-25 pg/mL |
|
Stage IV |
15.1 years |
10-46 pg/mL |
|
Stage V |
18 years |
10-60 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-29 pg/mL |
|
Stage II |
10.5 years |
10-33 pg/mL |
|
Stage III |
11.6 years |
15-43 pg/mL |
|
Stage IV |
12.3 years |
16-77 pg/mL |
|
Stage V |
14.5 years |
17-200 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) Performed
Monday through Saturday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82679
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| E1 | Estrone, S | 2258-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81418 | Estrone, S | 2258-2 |
Report Available
2 to 6 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)