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HelpTest Code AT III Anti Thrombin III Activity
Cerner Test Code
ATIIIAC
Acceptable Collection Tube(s) or Specimen
Blue
Specimen Draw Volume
Volume: 2.7 mL
Minimum Volume: 2.7 mL
Processing Instructions
Draw 2.7 ml in a Blue Top tube. Tube must be filled appropriately to the fill line to ensure accurate results. Centrifuge tube, aliquot 1.0 mL plasma, centrifuge plasma again, and place 1 ml of platelet-poor plasma in an aliquot tube and freeze.
Stability
Stability: Plasma: Room temp 2 hrs, Refrigerated 2 hrs, Frozen 24 months Whole Blood: tubes left capped/unspun are stable for 72 hours at room temperature.
Performed Test Frequency
Monday|Wednesday|Friday
CPT(s)
85300
Methodology
Synthetic chromogenic substrate
Performing Location
MercyOne Des Moines Laboratory, Hematology
Rejection Criteria
Rejection criteria: Refrigerated plasma.
Clinical Significance
Since the first report (1965) of a hereditary deficiency of AT III and its consequences, AT III has been considered an important parameter in spontaneous thromboembolic disorders. The hereditary deficiency, either quantitative or qualitative, is less common than the acquired deficiency. An acquired AT III deficiency has been described in DIC, septic shock, nephrotic syndrome, liver disease and in L-asparaginase treatments. AT III can also be utilized to optimize heparin therapy and provide a more consistent state of anticoagulation during ECMO.